† (Co-) First Author ; * (Co-) Corresponding Author          

       5-Year Representative Publications

1. Guan G†, Li Z†, Ma Y†, Ye P†, Cao J, Wong MK, Ho VWS, Chan LY, Yan H*, Tang C*, Zhao Z*. Cell lineage-resolved embryonic morphological map reveals novel signaling regulating cell fate and size asymmetry. Nat. Commun. (2025)

2. Chen Y†, Guan G†, Tang LH*, Tang C*. Balancing reaction-diffusion network for cell polarization pattern with stability and asymmetry. eLife (2025)

3. Kuang X†, Guan G†, Wong MK, Chan LY, Zhao Z, Tang C*, Zhang L*. Computable early Caenorhabditis elegans embryo with a phase field model. PLoS Comput. Biol. (2022)

4. Guan G†, Wong MK, Zhao Z, Tang LH*, Tang C*. Volume segregation programming in a nematode's early embryogenesis. Phys. Rev. E (2021)

5. Cao J†, Guan G†, Ho VWS†, Wong MK, Chan LY, Tang C*, Zhao Z*, Yan H*. Establishment of a morphological atlas of the Caenorhabditis elegans embryo using deep-learning-based 4D segmentation. Nat. Commun. (2020)

       Full Publications

6. Li Z†*, Cao J, Guan G*, Zhao Z, Yan H. 3DCSQ: An effective method for quantification, visualization and analysis of 3D cell shape during early embryogenesis. Quant. Biol. (2024)

7. Guan G†, Chen Y†, Wang H*, Ouyang Q, Tang C*. Characterizing cellular physiological states with 3D shape descriptors for cell membranes. Membranes (2024) - Issue Cover

8. Cao J†*, Hu L, Guan G*, Li Z, Tang C, Zhao Z, Yan H. CShaperApp: Segmenting and analyzing cellular morphologies of the developing Caenorhabditis elegans embryo. Quant. Biol. (2024)

9. Guan G†, Luo C†, Tang LH*, Tang C*. Modulating cell proliferation by asymmetric division: A conserved pattern in the early embryogenesis of nematode species. MicroPubl. Biol. (2024)

10. Kuang X†, Guan G†, Tang C*, Zhang L*. MorphoSim: An efficient and scalable phase-field framework for accurately simulating multicellular morphologies. npj Syst. Biol. Appl. (2023)

11. Guan G†, Kuang X†, Tang C*, Zhang L*. Comparison between phase-field model and coarse-grained model for characterizing cell-resolved morphological and mechanical properties in a multicellular system. Commun. Nonlinear Sci. Numer. Simul. (2023)

12. Wong MK†, Ho VWS†, Huang X, Chan LY, Xie D, Li R, Ren X, Guan G, Ma Y, Hu B, Yan H, Zhao Z*. Initial characterization of gap phase introduction in every cell cycle of C. elegans embryogenesis. Front. Cell Dev. Biol. (2022)

13. Guan G†, Zhao Z*, Tang C*. Delineating the mechanisms and design principles of Caenorhabditis elegans embryogenesis using in toto high-resolution imaging data and computational modeling. Comput. Struct. Biotechnol. J. (2022)

14. Guan G†*, Wong MK, Chan LY, Ho VWS, An X, Zhao Z, Tang C. Investigating spatio-temporal cellular interactions in embryonic morphogenesis by 4D nucleus tracking and systematic comparative analysis - Taking nematodes C. elegans and C. briggsae as examples. The IEEE 9th International Conference on Bioinformatics and Computational Biology (ICBCB) (2021)

15. Guan G†, Fang M†, Wong MK, Ho VWS, An X, Tang C, Huang X*, Zhao Z*. Multilevel regulation of muscle-specific transcription factor hlh-1 during Caenorhabditis elegans embryogenesis. Dev. Genes Evol. (2020)

16. Guan G†*, Tang LH, Tang C. Reconstructing the multicellular structure of a developing metazoan embryo with repulsion-attraction model and cell-cell connection atlas in vivo. J. Phys.: Conf. Ser. (2020)

17. Tian B†, Guan G, Tang LH, Tang C*. Why and how the nematode’s early embryogenesis can be precise and robust: A mechanical perspective. Phys. Biol. (2020)

18. Chen L†, Guan G†, Liu Q, Yuan S, Yan T, Tian L, Zhou Y, Zhao Y, Ma Y, Wei T*, Fu X*. Characterization and complete genomic analysis of two Salmonella phages, SenALZ1 and SenASZ3, new members of the genus Cba120virus. Arch. Virol. (2019)

19. Liu S†, Guan G, Peng S, Lin F*. Rebounding motion of a highly elastic ball between two parallel matte plates. Am. J. Phys. (2018)

20. Zhao J†, Guan G, Lin F*. Light rings generated by surface capillary wave and laser illumination together. Phys. Eng. (2018)

21. Mu X†, Guan G, Zhang B, Lin F*. Varied motion modes of light objects rolling on a horizontally rotating disk. Mech. Eng. (2017)

22. Guan G†, Huang J, Lin F*. Circle of light generated by cylindrical wire obliquely illuminated by laser. Appl. Phys. (2017)

23. Tan D†, Guan G, Lin F*. A new non-contact method for measuring glass thickness with laser interference. Appl. Phys. (2017)

       Prepublications

1. Guan G†, Budjan C, Shao C, Hormoz S*. Wnt-Nodal signalings coordinate intercellular short-range repulsion and long-range attraction for 3D human embryoid patterning. In Preparation (2025)

2. Guan G†, Wang S, Shields G, Ye J, Budjan C, Shao C, Hormoz S*. Deciphering biochemical and biomechanical networks capable of self-organizing symmetry breaking in 3D human embryoid. In Preparation (2025)

3. Toda S†, Guan G†, Wasinger S, Lim W*. Robust cellular pattern formation synthetic gene circuits that integrate reaction diffusion signaling with mechanical regulation. In Preparation (2025)

4. Guan G†, Chen Y†, Wang H*. Decoding genetic and morphological regulatory architectures in development. In Preparation (2025)

5. Guan G†, Gao D†, Tang C*, Ma R*. Cell division and asymmetry modulated by membrane mechanics In Preparation (2025)

6. Zhang Q†, Guan G†, Yu C†, Luo R, Yiu SM*, Wu T*. Autonomous prediction for 3D cell morphology trajectory via deep learning and physical principles. In Preparation (2025)

7. Liu C†, Liu Y*, Guan G*. A diversity-repeatability trade‑off in cell fate coding underlies complex development. In Preparation (2025)

8. Li Z†, Ma Y, Huang Z*, You S, Zhu Z, Xie D, Lee D, Cao J, Guan G*, Zhao Z*, Yan H*. Deep-transformer-based 3D cell membrane tracking enables subcellular-resolved spatiotemporal molecular quantification. In Preparation (2025)

9. Guan G†, Wong MK†, Ho VWS, An X, Chan LY, Tian B, Li Z, Tang LH*, Zhao Z*, Tang C*. System-level quantification and phenotyping of early embryonic morphogenesis of Caenorhabditis elegans. To be Submitted Soon; bioRxiv, https://doi.org/10.1101/776062 (2019)

10. Guan G†, Zhang Q†, Kuang X†, Zhang L*, Tang C*. Efficient co-programming of intercellular mechanics and signaling for complex developmental patterns. Cell Rep. Phys. Sci., Under Review (2025)

11. Guan G†*, Zhao C†, Li Z†, Zhang P, Chen Y, Ye P, Wong MK, Chan LY, Yan H, Tang C, Zhao Z*. EmbSAM: Cell boundary localization and Segment Anything Model for fast images of developing embryos. Commun. Biol., Under Review; bioRxiv, https://doi.org/10.1101/2024.09.07.611795 (2025)

12. Miao J†*, Guan G†, Tang C*. Spontaneous mechanical and energetic state transitions during Caenorhabditis elegans gastrulation. eLife, Under Revision; arXiv, https://doi.org/10.48550/arXiv.2105.05795 (2025)

13. Pahng SH†, Guan G, Fefferman B, Hormoz S*. DiffeoMorph: Learning to morph 3D shapes using differentiable agent-based simulations. The 39th Annual Conference on Neural Information Processing Systems (NeurIPS), Under Review (2025)

14. Zhao C†, Luo Z†, Guan G†, Li Z, Ma Y, Zhao Z*, Wan R*. CellINR: Implicitly overcoming background fluorescence noise of microscopy imaging. The 39th Annual Conference on Neural Information Processing Systems (NeurIPS), Under Review (2025)

       Patents and Software

1. Software Registration, 2022SR1454264, Active

2. Guan G, Zhao J, Lin F. CN206497007U, Active

3. Guan G, Tan D, Yao X. CN209606016U, Active

4. Tan D, Guan G. CN209765851U, Active

5. Zhang L, Kuang X, Guan G, Tang C. CN114970169A, Under Revision

6. Guo J, Yu H, Huang Y, Guan G. CN110129350A, Pending

7. Guan G, Tan D, Yao X, Hu Z. CN108525268A, Active

8. Guan G, Tan D, Yao X, Hu Z. CN208525771U, Active

9. Tan D, Guan G, Lin F. CN106871797A, Active

10. Tan D, Guan G, Lin F. CN206362308U, Active

11. Tan D, Guan G, Yao X. CN208621467U, Active

12. Tan D, Guan G, Yao X. CN109060604A, Active